Neonatal Guidelines 2025–2028: Ensuring Excellence in Newborn Care The Neonatal Guidelines 2025–2028 represent the latest evidence-based framework developed to enhance the quality, consistency, and outcomes of neonatal care worldwide. These guidelines provide updated clinical protocols for the assessment, stabilization, treatment, and long-term management of newborns—especially those born preterm or with critical health conditions. Key updates in the 2025–2028 edition include: Revised standards for neonatal resuscitation, incorporating the latest recommendations on delayed cord clamping and thermoregulation. Enhanced protocols for sepsis screening and antibiotic stewardship, aiming to reduce antimicrobial resistance. Updated nutritional guidelines, including human milk fortification strategies and support for early enteral feeding. Expanded recommendations for family-centered care, with a focus on parental engagement and mental health. Integration of digital health tools and telemedicine, improving access to neonatal expertise in remote and underserved areas. Stronger emphasis on neurodevelopmental follow-up for high-risk infants, with early intervention pathways. Developed by a panel of neonatologists, pediatricians, nurses, and public health experts, the guidelines serve as a cornerstone for hospitals, NICUs, and healthcare systems striving for high-quality neonatal outcomes. The 2025–2028 edition reflects a global commitment to equity, innovation, and sustainability in newborn care.