Antitargets and Drug Safety (Methods & Principles in Medicinal Chemistry Book 66) 1st Edition

Antitargets and Drug Safety (Methods & Principles in Medicinal Chemistry Book 66) 1st Edition

Antitargets and Drug Safety (Methods & Principles in Medicinal Chemistry, Book 66) – 1st Edition is an authoritative and highly specialized reference that addresses one of the most critical challenges in modern drug development: drug safety and off-target effects. This book is essential reading for medicinal chemists, pharmaceutical scientists, toxicologists, pharmacologists, and advanced postgraduate students involved in drug discovery and development.

The book focuses on antitargets—biological targets whose unintended interaction with drug candidates can lead to toxicity, adverse drug reactions, or late-stage clinical failure. By understanding these antitargets early in the drug development process, researchers can significantly reduce attrition rates and improve the safety profile of new therapeutic agents.

This first edition provides a comprehensive overview of known drug antitargets, including ion channels, enzymes, transporters, and receptors that are commonly associated with cardiotoxicity, hepatotoxicity, neurotoxicity, and other safety liabilities. The book explains the molecular and biochemical mechanisms underlying these adverse effects, offering valuable insights into how unwanted interactions occur at the cellular and systemic levels.

A major strength of the book is its emphasis on predictive safety assessment. It discusses modern approaches such as in vitro assays, in silico modeling, structure–activity relationship (SAR) analysis, and early toxicological screening used to identify antitarget interactions during lead optimization. These methodologies are presented within the broader framework of medicinal chemistry principles, making the content both practical and scientifically rigorous.

As part of the respected Methods & Principles in Medicinal Chemistry series, Book 66 maintains a high academic standard while remaining applicable to real-world pharmaceutical research. The chapters are written by experts in drug safety and medicinal chemistry, ensuring reliable, up-to-date information.

Available on TheBookLance, Antitargets and Drug Safety is an indispensable resource for professionals seeking to design safer, more effective drugs and for institutions focusing on advanced pharmaceutical education and research.

Key Features

• In-depth coverage of antitargets in drug discovery

• Focus on drug safety and adverse effect mechanisms

• Detailed discussion of cardio-, hepato-, and neurotoxicity

• Modern tools for early safety and toxicity prediction

• Integration of medicinal chemistry and toxicology principles

• Expert-authored chapters with scientific depth

• Part of the renowned Methods & Principles in Medicinal Chemistry series

• Ideal for researchers, professionals, and postgraduate students

• Comprehensive 1st Edition reference for safer drug design